Safety and Hazards
Information on safety and hazards for this compound, including safety/hazards properties, reactivity, incompatibilities, management techniques, first aid treatments, and more. For toxicity and related information, please see the Toxicity section.
Hazards Identification
This section identifies the hazards of the chemical presented on the safety data sheet (SDS) and the appropriate warning information associated with those hazards. The information in this section includes, but are not limited to, the hazard classification of the chemical, signal word, pictograms, hazard statements and precautionary statements.
GHS Classification
GHS (Globally Harmonized System of Classification and Labelling of Chemicals) is a United Nations system to identify hazardous chemicals and to inform users about these hazards. GHS has been adopted by many countries around the world and is now also used as the basis for international and national transport regulations for dangerous goods. The GHS hazard statements, class categories, pictograms, signal words, and the precautionary statements can be found on the PubChem GHS page.
This chemical does not meet GHS hazard criteria for 0.1% (2 of 1512) of reports.
Warning
H373 (99.7%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H411 (99.7%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
Aggregated GHS information provided per 1512 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria per 2 of 1512 reports by companies.
There are 22 notifications provided by 1510 of 1512 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.ECHA C&L website.
Warning
H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
Aggregated GHS information provided per 42 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.ECHA C&L website.
Danger
H302: Harmful if swallowed [Warning Acute toxicity, oral]
H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
P260, P264, P264+P265, P270, P280, P301+P317, P305+P354+P338, P317, P319, P330, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning
H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]
P203, P280, P318, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger
H302: Harmful if swallowed [Warning Acute toxicity, oral]
H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]
H360: May damage fertility or the unborn child [Danger Reproductive toxicity]
H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
P203, P260, P264, P264+P265, P270, P280, P301+P317, P305+P354+P338, P317, P318, P319, P330, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Hazard Classes and Categories
The Hazard Classes and Categories are aligned with GHS (Globally Harmonized System of Classification and Labelling of Chemicals) hazard statement codes. The percentage data in the parenthesis from ECHA indicates that the hazard classes and categories information are consolidated from multiple companies. Also, see the detailed explanation from the above GHS classification section.
STOT RE 2 (99.7%)
Aquatic Chronic 2 (99.7%)
STOT RE 2 (100%)
Aquatic Chronic 2 (100%)
Acute toxicity - category 4
Eye damage - category 1
Specific target organ toxicity (repeated exposure) - category 1
Germ cell mutagenicity - Category 2
Acute toxicity (Oral) - Category 4
Serious eye damage/eye irritation - Category 1
Germ cell mutagenicity - Category 2
Reproductive toxicity - Category 1B
Specific target organ toxicity - Repeated exposure - Category 1 (central nervous system, respiratory organs)
Health Hazards
Description of the chemical's health hazards (e.g., toxicity, corrosivity, and flammability) that can have negative impacts on our short- or long-term health.
SYMPTOMS: Symptoms of exposure to this compound include mild irritation of the eyes and mucous membranes of the respiratory tract. Symptoms of exposure to this type of compound include apathy, anorexia, headache, recurring leg cramps, loss of balance, clumsiness, pneumonia and associated pulmonary problems. Other symptoms include central nervous system damage, pulmonary system damage, upper respiratory infections, languor, sleepiness, weakness in the legs, a stolid, mask-like face, muscular twitchings, varying from a fine tremor of the hands to coarse, rhythmical movements of the arms, legs and trunk; slight increase in tendon reflexes, ankle and patellar clonus, typical Parkinsonian slapping gait and minute handwriting (affected by micrographia). It can cause spastic gait, insomnia, dystonia, fatiguability, asthenia and an inability to concentrate. It can also cause impaired mentation, ataxia, difficulty in walking and decreased movement of the eyelids and eyes. Other symptoms include lethargy, edema, extrapyramidal effects, sleep disturbances, dermatitis, irritability, liver enlargement, increased muscle tone, muscular cramps, mental deterioration, excessive salivation and perspiration, sexual disturbances, blood changes and, very rarely, hypothyroidism. Exposure can cause spasms, arthralgias and speech disturbances such as slurred speech, slow and monotonous voice tone, inability to speak above a whisper, difficult articulation and incoherence, and even complete muteness. Psychosis may occur with unaccountable laughter, euphoria, impulsive acts, absentmindedness, mental confusion, aggressiveness and hallucinations. Propulsion, retropropulsion and lateropropulsion are affected with no movement for protection when falling. Absolute detachment may occur, broken by sporadic or spasmodic laughter. Inhalation may cause acute bronchitis, nasopharyngitis and itching. Numbness of the extremities and impairment of libido may occur. Other effects include weakness, delusions, compulsions, rigidity, bradykinesia, sudden crying, stuttering, hoarse voice, nervousness, inability to walk backward, hyporeflexia, Romberg's sign, adiadochokinesia, forgetfulness, general malaise, drowsiness, stiffness of the arms or legs, urinary difficulty, somnolence, sexual excitement followed by impotence, "hen's gait" and frequent falling. Fever may occur, with chills, upset stomach (nausea), vomiting, dryness of the throat, cough and body aches. Other symptoms include trouble with memory and judgment, unstable emotions, incoordination, chest pain, restlessness, double vision, impaired hearing, anemia, lassitude and low back pain. Symptoms of exposure may simulate progressive bulbar paralysis, post-encephalitic Parkinsonism, multiple sclerosis, amyotrophic lateral sclerosis and progressive lenticular degeneration (Wilson's Disease).
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of sulfur oxides. (NTP, 1992)
Fire Hazards
Fire hazard means any situation, process, material or condition which may cause a fire or explosion or provide a ready fuel supply to increase the spread or intensity of the fire or explosion and which poses a threat to life or property. This section provides information on fire hazards involving this chemical.
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Hazards Summary
This section provides an overview of the key hazards information of this compound.
No evidence of carcinogenicity in rats and equivocal evidence in mice in 2-year feeding studies; [NTP] Intermittent inhalation studies of rats produced changes in testicular weight (0.5 mg/m3 for 45 days) and degenerative changes to brain (0.01 mg/m3 for 13 weeks); [RTECS] May cause irritation; Targets lungs and nerves; [Aldrich MSDS] See Manganese and linked occupational diseases.
First Aid Measures
This section describes the initial care that should be given to an individual who has been exposed to the chemical. The information in this section includes the description of the symptoms or effects of exposure to the chemical, necessary first-aid instructions by relevant routes of exposure (inhalation, skin and eye contact, and ingestion), and recommendations for immediate medical care and special treatment needed, when necessary.
Fresh air, rest.
Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
Rinse mouth. Seek medical attention if you feel unwell.
First Aid
First aid measures for exposure to this chemical through various routes (for example, ingestion, inhalation, skin contact, and eye contact).
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
Fire Fighting
This section provides fire fighting information, including fire fighting procedures and hazards.
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
In case of fire in the surroundings, use appropriate extinguishing media.
Accidental Release Measures
This section provides recommendations on the appropriate response to spills, leaks, or releases, including containment and cleanup practices to prevent or minimize exposure to people, properties, or the environment. It may also include recommendations distinguishing between responses for large and small spills where the spill volume has a significant impact on the hazard.
Isolation and Evacuation
Isolation and evacuation measures to take when a large amount of this chemical is accidentally released in an emergency.
Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Spillage Disposal
Methods for containment and safety measures to protect workers dealing with a spillage of this chemical.
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Store and dispose of according to local regulations.
Handling and Storage
This section provides guidance on the safe handling practices and storage conditions for this chemical. The information in this section includes precautions for safe handling, such as recommendations for handling incompatible chemicals, minimizing the release of the chemical into the environment, and providing advice on general hygiene practices (e.g., eating, drinking, and smoking in work areas is prohibited). In addition, this section provides recommendations on the conditions for safe storage (including any incompatibilities) as well as advice on specific storage requirements (e.g., ventilation requirements).
Nonfire Spill Response
Emergency response measures to take in the event of a chemical spill (without a fire).
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should store this chemical under ambient temperatures, and protect it from moisture. If possible, it would be prudent to store this compound under inert atmosphere. (NTP, 1992)
Safe Storage
Measures to take for safe storage of this chemical.
Dry. Well closed. Store in an area without drain or sewer access.
Exposure Control and Personal Protection
This section provides information on the exposure limits, engineering controls, and personal protective measures that can be used to minimize worker exposure. The information in this section includes OSHA Permissible Exposure Limits (PELs), American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Values (TLVs), and any other exposure limit used or recommended by the chemical manufacturer, importer, or employer preparing the safety data sheet, where available. In addition, this section contains information on appropriate engineering controls (e.g., use local exhaust ventilation, or use only in an enclosed system) as well as recommendations for personal protective measures to prevent illness or injury from exposure to chemicals, such as personal protective equipment (PPE) (e.g., appropriate types of eye, face, skin or respiratory protection needed based on hazards and potential exposure).
0.2 [mg/m3], as Mn (inhalable fraction), 0.02 mg/m3, as Mn (respirable fraction)[German Research Foundation (DFG)]
Immediately Dangerous to Life or Health (IDLH)
The Immediately Dangerous to Life or Health air concentration values (IDLH values) characterize high-risk exposure concentrations and conditions and are used as a component of respirator selection criteria. IDLH values are established (1) to ensure that the worker can escape from a given contaminated environment in the event of failure of the respiratory protection equipment and (2) to indicate a maximum level above which only a highly reliable breathing apparatus, providing maximum worker protection, is permitted.
500 mg Mn/m3 (NIOSH, 2024)
Threshold Limit Values (TLV)
The threshold limit value (TLV) of a chemical is an airborne concentration at which a worker can be exposed day after day for a working lifetime without adverse effect. There are three types of TLVs for chemicals. [1] Threshold limit value - time-weighted average (TLV-TWA): average exposure on the basis of a 8h/day, 40h/week work schedule. [2] Threshold limit value - short-term exposure limit (TLV-STEL): a 15-minute TWA exposure that should not be exceeded at any time during a workday, even if the 8-hour TWA is within the TLV-TWA. [3] Threshold limit value - ceiling limit (TLV-C): absolute exposure limit that should not be exceeded at any time. TLVs are developed by the American Conference of Governmental Industrial Hygienist. While TLVs are widely accepted occupational exposure limits, they are not standards enforced by the U.S. Government.
0.02 [mg/m3], as Mn (respirable fraction), 0.1 mg/m3, as Mn (inhalable fraction)
(as Mn, respirable fraction): 0.02 mg/m
Occupational Exposure Limits (OEL)
In general, the occupational exposure limit (OEL) indicates the level of admissible exposure, for a length of time (usually 8 hours), to a chemical or physical hazard that is not likely to affect the health of a worker. The OELs for chemical substances are established based on the chemical properties of the substance, experimental studies on animals and humans, toxicological and epidemiological data. These limits are set out by many professional organizations and government agencies around the world, such as the American Conference of Governmental Industrial Hygienists (ACGIH), and the National Institute for Occupational Safety and Health (NIOSH) in the United States. Different organizations may use different terminology for the OEL. For example, the ACGIH term for OEL is "Threshold Limit Value" (TLV)® while the NIOSH term is "recommended exposure limits" (REL). This section also includes MAK (maximale arbeitsplatzkonzentration), similar to threshold limit value, specifies the maximum concentration level of a toxic substance in air at a workplace.
(as Mn, respirable fraction): 0.05 mg/m
(as Mn, respirable fraction): 0.02 mg/m
Inhalation Risk
Risk of exposure to this chemical through inhalation. Note that the terms "risk" and "hazard" have different meanings. A hazard is something that has the potential to cause harm, while risk is the likelihood of harm taking place, based on exposure to that hazard.
Evaporation at 20Â °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
Effects of Short Term Exposure
This section provides health effects of short-term exposure to this compound. The short-term exposure (also called acute exposure) is a short contact with a chemical. It may last a few seconds or a few hours. For example, it might take a few minutes to clean windows with ammonia, use nail polish remover or spray a can of paint. The fumes someone might inhale during these activities are examples of acute exposures.
The substance is irritating to the eyes.
Effects of Long Term Exposure
This section provides health effects of long-term exposure to this compound. The long-term exposure (also called chronic exposure) is continuous or repeated contact with a toxic chemical over a long period of time (months or years). If a chemical is used every day on the job, the exposure would be chronic. Over time, some chemicals, such as PCBs and lead, can build up in the body. Chronic exposures can also occur at home. Some chemicals in household furniture, carpeting or cleaners can be sources of chronic exposure.
The substance may have effects on the central nervous system. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Personal Protective Equipment (PPE)
Personal protective equipment (PPE) to use when handling this chemical.
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Exposure Prevention
Prevention measures to avoid exposure to this chemical through various routes (for example, ingestion, inhalation, skin contact, and eye contact).
PREVENT DISPERSION OF DUST!
Inhalation Prevention
Precautionary measures to avoid inhalation of this chemical.
Use local exhaust or breathing protection.
Skin Prevention
Precautionary measures to avoid skin exposure to this chemical.
Protective gloves.
Eye Prevention
Precautionary measures to avoid eye exposure to this chemical.
Wear safety spectacles or eye protection in combination with breathing protection if powder.
Ingestion Prevention
Precautionary measures to avoid ingestion of this chemical.
Do not eat, drink, or smoke during work.
Stability and Reactivity
This section describes the stability and reactivity hazards of the chemical. For some compounds, related information may also be found in the "Stability/Shelf Life" section under Experimental Properties (if available).
Air and Water Reactions
Special alerts if this chemical reacts with air, water, or moisture.
Water soluble. Hygroscopic.
Reactive Group
List of reactive groups that this chemical belongs to, according to CAMEO Chemicals at the U.S. National Oceanic and Atmospheric Administration (NOAA).
Salts, Acidic
Reactivity Profile
Description of the chemical's potential reactivity with other chemicals, air, and water. Also it includes any other intrinsic reactive hazards (such as polymerizable or peroxidizable).
MANGANESE(II) SULFATE MONOHYDRATE is incompatible with aluminum and magnesium. (NTP, 1992)
Transport Information
Transport information lists the U.S. Department of Transportation (DOT) requirements and related information for shipping and transporting of hazardous chemical(s) by road, air, rail, or sea.
DOT Label
U.S. Department of Transportation (DOT) hazard warning label for the chemical (such as flammable liquid or corrosive). This label must be displayed on shipped packages, railroad tank cars, and tank trucks according to specifications described in 49 CFR 172.
Class 9
UN Classification
Classification of this chemical, according to the Agreement concerning the International Carriage of Dangerous Goods by Road (ADR). ADR is a United Nations treaty that governs transnational transport of hazardous materials.
UN Hazard Class: 9; UN Pack Group: III
Regulatory Information
This section lists the regulations related to the safety, health, and environment of the chemical and its associated products. The regulatory information, which may encompass national and/or regional regulations pertaining to the chemical or mixtures, is presented solely for informational purposes. For additional details, please consult the links to the information sources provided under each data entry.
Chemical: Sulfuric acid, manganese(2+) salt (1:1), monohydrate
Manganese (II) sulphate, monohydrate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety Information
Miscellaneous safety information for this chemical that is not shown in other sections, such as history, incidents, special reports, and so on.
IMAP assessments - Soluble manganese compounds: Human health tier II assessment